Role of oxidative phosphorylation and ATP release in mediating birth-related pulmonary vasodilation in fetal lambs. Am J Physiol Heart Circ Physiol 2002 Oct;283(4):H1600-8
Date
09/18/2002Pubmed ID
12234814DOI
10.1152/ajpheart.00245.2002Scopus ID
2-s2.0-0036783629 (requires institutional sign-in at Scopus site) 29 CitationsAbstract
We investigated the hypothesis that birth-related pulmonary vasodilation is mediated in part by an increase in oxidative phosphorylation and ATP release in response to oxygen exposure at birth. Studies were done in fetal lambs to evaluate the independent effects of oxygen, lung distension alone, or lung distension accompanied by oxygenation and shear stress on fetal pulmonary blood flow and resistance and plasma ATP levels in the pulmonary artery. The effect of each intervention was evaluated in lambs assigned to one of three groups: control or pretreatment with 2,4-dinitrophenol or antimycin-A, inhibitors of oxidative phosphorylation. Exposure to oxygen alone or with lung distension was associated with increases in plasma ATP levels and pulmonary blood flow and a decrease in pulmonary vascular resistance. Plasma ATP levels did not change during lung distension alone. 2,4-Dinitrophenol and antimycin-A attenuated the pulmonary vasodilator response to oxygen but did not attenuate the response to lung distension alone. An increase in oxidative phosphorylation and ATP release during oxygen exposure may contribute to birth-related pulmonary vasodilation in fetal lambs.
Author List
Konduri GG, Mattei JAuthor
Girija Ganesh Konduri MD Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AcetylcholineAdenosine Triphosphate
Animals
Animals, Newborn
Female
Labor, Obstetric
Lung
Nitric Oxide Donors
Oxidative Phosphorylation
Oxygen
Penicillamine
Pregnancy
Pulmonary Circulation
Sheep
Stress, Mechanical
Vascular Resistance
Vasodilation
Vasodilator Agents
