Faculty Collaboration Database

Effect of amlodipine on myocardial functional and metabolic recovery following coronary occlusion and reperfusion in dogs. Cardiovasc Drugs Ther 1989 Aug;3(4):535-43

Date

08/01/1989

Pubmed ID

2535101

DOI

10.1007/BF01865513

Scopus ID

2-s2.0-0024433224 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

The effects of the dihydropyridine calcium-channel blocker, amlodipine, on subendocardial segment shortening (%SS), regional myocardial blood flow, myocardial high-energy phosphate levels and tissue water content were compared to those of a saline-treated group of barbital-anesthetized dogs subjected to a 45-minute coronary artery occlusion followed by 60 minutes of reperfusion. Saline or amlodipine (200 micrograms/kg, IV) were administered 15 minutes prior to coronary occlusion. There were no significant differences between groups in ischemic bed size or hemodynamics, although dP/dt was higher following amlodipine. Subepicardial collateral blood flow was higher in the amlodipine group during coronary occlusion. Following occlusion, %SS in the ischemic region was markedly decreased in both series and passive systolic lengthening resulted. In spite of similar decreases in %SS during occlusion, the amlodipine- treated dogs showed a marked improvement in myocardial segment function (%SS) of the ischemic-reperfused region throughout 60 minutes of reperfusion as compared to saline-treated animals. In addition, amlodipine prevented the rebound increase in phosphocreatine and attenuated the loss of adenine nucleotides and the increase in tissue water in the ischemic-reperfused area at 60 minutes of reperfusion. These results suggest that amlodipine has a favorable effect on the functional and metabolic recovery of the ischemic-reperfused myocardium, and may have potential as a therapeutic agent for the treatment of coronary artery disease. The mechanism of action of amlodipine in this model is unknown but may be partially related to a drug-induced increase in coronary collateral blood flow.

Author List

Gross GJ, Farber NE, Pieper GM

MESH terms used to index this publication - Major topics in bold

Adenine Nucleotides
Amlodipine
Animals
Calcium Channel Blockers
Coronary Disease
Coronary Vessels
Dogs
Female
Heart
Hemodynamics
Male
Myocardial Reperfusion Injury
Myocardium
Nifedipine
Phosphates
Phosphocreatine
Water