Parental infertility, infertility treatment and hepatoblastoma: a report from the Children's Oncology Group. Hum Reprod 2012 Jun;27(6):1649-56
Date
04/05/2012Pubmed ID
22473396Pubmed Central ID
PMC3357199DOI
10.1093/humrep/des109Scopus ID
2-s2.0-84861568458 (requires institutional sign-in at Scopus site) 29 CitationsAbstract
BACKGROUND: A recent study suggested a markedly increased risk of hepatoblastoma (HB) among children conceived with treatment for infertility. However, it is not clear whether this finding is confounded by the association between HB and low birthweight (LBW).
METHODS: Associations between parental infertility and its treatment and HB were examined using data from a case-control study conducted through the Children's Oncology Group (COG). Telephone interviews were completed for 383 mothers of cases diagnosed with HB at US COG institutions between January 2000 and December 2008 and for 387 mothers of controls recruited through state birth registries. Logistic regression was used to examine possible associations.
RESULTS: After adjusting for birthweight and other potential confounders, no significant association was found for any of the measures of parental infertility or its treatment. In HB cases conceived through assisted reproductive technology (ART), 4 of 16 also had Beckwith-Wiedemann syndrome (BWS) compared with 9 of 365 in HB cases without ART.
CONCLUSIONS: Little evidence of an association between parental infertility or its treatment and HB was found. The relationship found in a previous study could be due to LBW and BWS which are risk factors for HB and also associated with parental infertility and its treatment.
Author List
Puumala SE, Ross JA, Feusner JH, Tomlinson GE, Malogolowkin MH, Krailo MD, Spector LGMESH terms used to index this publication - Major topics in bold
AdultBeckwith-Wiedemann Syndrome
Birth Weight
Case-Control Studies
Child
Child, Preschool
Female
Gestational Age
Hepatoblastoma
Humans
Infant
Infant, Low Birth Weight
Infant, Newborn
Infertility
Liver Neoplasms
Male
Pregnancy
Premature Birth
Reproductive Techniques, Assisted
