Principles of antiretroviral treatment of children and adolescents with human immunodeficiency virus infection. Semin Pediatr Infect Dis 2003 Oct;14(4):269-85
Date
01/16/2004Pubmed ID
14724792DOI
10.1053/j.spid.2003.09.005Scopus ID
2-s2.0-0942276966 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Human immunodeficiency virus (HIV) infection requires life-long therapy to attain durable suppression of HIV replication and prevent or reverse HIV-related symptoms or immune system dysfunction. Combination therapy with 3 or more antiretroviral medications is currently widely recommended for treatment of children and adolescents with HIV infection. While potent regimens can initially reduce virus load to below assay quantitation limits in the majority of persons with HIV infection, 30% to 80% of children will have regimen failure and return of detectable plasma virus within 1 year. Adherence to therapy is critical to regimen success. Optimal treatment requires careful use of potent combinations of drugs, with attention to adherence, palatability, toxicity, and pharmacokinetics. Practitioners with experience caring for children and adolescents with HIV infection should be involved.
Author List
Havens PLMESH terms used to index this publication - Major topics in bold
AdolescentAnti-HIV Agents
Child
Child, Preschool
Drug Therapy, Combination
HIV Infections
HIV-1
Humans
Infant
Infant, Newborn
Patient Compliance
Virus Replication
