Rat model of familial combined hyperlipidemia as a result of comparative mapping. Physiol Genomics 2004 Mar 12;17(1):38-47
Date
01/08/2004Pubmed ID
14709677DOI
10.1152/physiolgenomics.00043.2003Scopus ID
2-s2.0-3142734395 (requires institutional sign-in at Scopus site) 42 CitationsAbstract
Total genome scan was carried out in 266 F2 intercrosses from the Prague hypertriglyceridemic (HTG) rat that shares several clinical characteristics with human metabolic syndrome. Two loci for plasma triglycerides (TG) were localized on chromosome 2 (Chr 2) (LOD 4.4, 3.2). The first locus overlapped with the rat syntenic region of the human locus for the metabolic syndrome and for small, dense LDL, while the second overlapped with the syntenic region of another locus for small, dense LDL in humans by the comparative mapping approach. Loci for TG on rat Chr 13 (LOD 3.3) and Chr 1 (LOD 2.7) overlapped with the syntenic region of loci for human familial combined hyperlipidemia (FCHL) in Finnish and Dutch populations, respectively. The concordances of loci for TG localized in this study with previously reported loci for FCHL and its related phenotypes are underlying the generalized importance of these loci in dyslipidemia. These data suggest the close relationship between dyslipidemia in HTG rats and human FCHL, establishing a novel animal model for exploration of pathophysiology and therapy based on genomic determinants.
Author List
Ueno T, Tremblay J, Kunes J, Zicha J, Dobesova Z, Pausova Z, Deng AY, Sun YL, Jacob HJ, Hamet PMESH terms used to index this publication - Major topics in bold
AnimalsCholesterol
Chromosome Mapping
Disease Models, Animal
Female
Genetic Linkage
Genetic Markers
Genetic Testing
Genome
Humans
Hyperlipidemia, Familial Combined
Male
Phenotype
Quantitative Trait Loci
Rats
Rats, Inbred Lew
Rats, Wistar
Sex Characteristics
Triglycerides
