Extracolonic gastrointestinal tract morphologic findings in a case of pseudomembranous collagenous colitis. Ann Diagn Pathol 2013 Jun;17(3):291-4
Date
06/05/2012Pubmed ID
22658854DOI
10.1016/j.anndiagpath.2012.04.003Scopus ID
2-s2.0-84877709904 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
"Pseudomembranous collagenous colitis" is a morphologic variant of collagenous colitis in which active inflammation with pseudomembrane formation is prominent and which has been associated with infectious, toxic, and ischemic etiologies. However, extracolonic morphologic findings in patients with pseudomembranous collagenous colitis have not been previously described. Here, we present a case of a patient with pseudomembranous collagenous colitis with abnormal extracolonic findings. These include gastric antral mucosa with histologic features reminiscent of ischemic injury and reactive gastropathy with intraepithelial lymphocytosis and partial villous atrophy in the duodenal and ileal biopsies. The findings in the small intestinal biopsies resemble those seen in enteric mucosa in patients with conventional collagenous colitis. Our pathologic findings as well as the clinical course of the patient further emphasize the clinical and histologic similarities shared by pseudomembranous collagenous colitis and conventional collagenous colitis.
Author List
Fons ME, Stein DJ, Patel A, Ferrer MS, Ammon H, Mackinnon AC, Komorowski RA, Yan BCAuthor
Daniel J. Stein BS, MD Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedBudesonide
Colitis, Collagenous
Colon
Duodenum
Endoscopy, Gastrointestinal
Enterocolitis, Pseudomembranous
Female
Gastric Mucosa
Glucocorticoids
Humans
Ileum
Intestinal Mucosa
Intestine, Small
Pyloric Antrum
Treatment Outcome
