Effect of cyclooxygenase blockade on the beneficial actions of nicorandil in the stunned myocardium of dogs. Pharmacology 1989;38(6):341-51
Date
01/01/1989Pubmed ID
2530592DOI
10.1159/000138557Scopus ID
2-s2.0-0024412626 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
The effects of nicorandil, indomethacin and nicorandil + indomethacin on subendocardial segment shortening (%SS), regional myocardial blood flow and coronary venous thromboxane (TxA2) and prostacyclin (PGI2) levels were compared to those of a saline-treated group in anesthetized dogs subjected to a 15-min coronary artery occlusion and 3 h of reperfusion. During reperfusion, nicorandil markedly improved %SS in the ischemic-reperfused region compared to saline- and indomethacin-treated dogs. Indomethacin did not antagonize the beneficial effects of nicorandil. These results suggest that the beneficial actions of nicorandil in this model are not the result of an increase in PGI2 or decrease in TxA2 synthesis.
Author List
Gross GJ, Pieper GMMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Cardiomyopathies
Coronary Circulation
Cyclooxygenase Inhibitors
Dinoprostone
Dogs
Female
Heart Rate
Hemodynamics
In Vitro Techniques
Indomethacin
Male
Myocardial Reperfusion Injury
Niacinamide
Nicorandil
Prostaglandins
Thromboxane A2
Time Factors
Vasodilator Agents
