Protective effect of nicorandil on postischemic function and tissue adenine nucleotides following a brief period of low-flow global ischemia in the isolated perfused rat heart. Pharmacology 1989;38(4):205-13
Date
01/01/1989Pubmed ID
2526951DOI
10.1159/000138539Scopus ID
2-s2.0-0024594019 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
A new antianginal agent, nicorandil, was tested in an isolated perfused rat heart model. Hearts were subjected to 30 min of low-flow, global ischemia followed by 30 min of reperfusion in the presence or absence of nicorandil. Nicorandil (1,500 micrograms/l) significantly improved isovolumic left ventricular minute-work during reperfusion compared to untreated hearts. Nicorandil also prevented the rebound in cardiac phosphocreatine levels and the loss of total adenine nucleotides as a result of ischemia and reperfusion. The salient effect of nicorandil was independent of any alterations in the release of endogenous prostacyclin. These results suggest that nicorandil may possess a unique cytoprotective effect on the ischemic-reperfused myocardium.
Author List
Pieper GM, Gross GJMESH terms used to index this publication - Major topics in bold
Adenine NucleotidesAnimals
Coronary Disease
Epoprostenol
Heart
Heart Function Tests
In Vitro Techniques
Male
Monoamine Oxidase Inhibitors
Myocardium
Niacinamide
Nicorandil
Rats
Rats, Inbred Strains
Time Factors
