[The opiatergic link between the antiarrhythmic effect of adaptation and hypoxia in the model of ischemia and reperfusion in vivo]. Patol Fiziol Eksp Ter 2003(1):19-21
Date
03/26/2003Pubmed ID
12652938Scopus ID
2-s2.0-0037639778 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Rat adaptation to repeated periods of hypobaric hypoxia has been found to prevent the occurrence of ischemic and reperfusion ventricular arrhythmias on a 10-minte coronary artery occlusion model. Inhibition of delta-opioid receptors by intravenous administration of the selective delta-opioid antagonist TIPP (psi) in a dose of 0.5 mg/kg, intravenously (i.v.), completely abolished the antiarrhythmic effect of adaptation to hypoxia. Inhibition of mu-opioid receptors by CTAP (0.5 mg/kg, i.v.) or kappa-receptors by nor-binaltorphimine (9 mg/kg i.v.) had no effect on the incidence cardiac rhythm disturbances in adapted rats during coronary artery occlusion and reperfusion. Therefore, these findings suggest that delta-opioid receptors play an important role in inhibiting arrhythmia formation in this model.
Author List
Lishmanov IuB, Naryzhnaia NV, Maslov LN, Gross GJMESH terms used to index this publication - Major topics in bold
Adaptation, PhysiologicalAnimals
Arrhythmias, Cardiac
Disease Models, Animal
Hypoxia
Myocardial Ischemia
Myocardial Reperfusion
Naltrexone
Narcotic Antagonists
Oligopeptides
Peptide Fragments
Peptides
Rats
Receptors, Opioid, delta
Receptors, Opioid, kappa
Receptors, Opioid, mu
Somatostatin
Tetrahydroisoquinolines
