Faculty Collaboration Database

Effect of annual influenza immunization on antibody response in lung transplant patients. Prog Transplant 2009 Jun;19(2):153-9

Date

07/11/2009

Pubmed ID

19588665

Pubmed Central ID

PMC2872508

DOI

10.1177/152692480901900209

Scopus ID

2-s2.0-70349257399 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

BACKGROUND: Influenza viral infections cause significant morbidity and mortality each season. Lung transplant patients may be at higher risk because of their underlying pathophysiology. Although annual immunization is the standard of care, its efficacy remains largely unproven. Previous studies showed poor antibody response to influenza vaccine in lung transplant patients, but no data on the antibody response in consecutive seasons have been published.

METHODS: We studied antibody responses to influenza vaccine in 122 subjects: 66 lung transplant recipients, 28 control subjects, and 28 patients awaiting lung transplantation. We compared antibody response rates to individual viruses contained in influenza vaccines in consecutive years within the 3 groups. Serum antibody concentrations were measured at baseline and 2 to 4 weeks after vaccination by using the hemagglutination inhibition assay. Log-transformed antibody concentrations and incidence of serconversion and seroprotection were calculated.

RESULTS: Median log-transformed antibody responses were similar in consecutive seasons in lung transplant subjects. Incidences of seroprotection and seroconversion did not differ between consecutive seasons in lung transplant recipients.

CONCLUSIONS: Antibody responses were similar in consecutively measured years in lung transplant subjects. Annual influenza vaccination in lung transplant subjects produces similar immune responses in 2 consecutive years, indicating that these patients are not at significantly increased risk of vaccine failure.

Author List

Dopp JM, Wiegert NA, Moran JJ, Francois ML, Radford KL, Thomas H, Love RB, Hayney MS

MESH terms used to index this publication - Major topics in bold

Adult
Antibodies, Viral
Case-Control Studies
Child
Female
Humans
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype
Influenza B virus
Influenza Vaccines
Influenza, Human
Lung Transplantation
Male
Middle Aged
Statistics, Nonparametric
Time Factors
Transplantation Immunology
Treatment Outcome
Vaccination
Wisconsin