Influence of lung inflation reflex on vascular capacitance in the systemic circulation. Am J Physiol 1989 Nov;257(5 Pt 2):R1004-11
Date
11/01/1989Pubmed ID
2574009DOI
10.1152/ajpregu.1989.257.5.R1004Scopus ID
2-s2.0-0024404921 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
The effects of sustained lung inflation on systemic vascular capacitance (SVC), systemic vascular resistance (SVR), and cardiac sympathetic efferent nerve activity (SENA) were investigated in anesthetized dogs. By use of a total cardiopulmonary bypass, the lungs were inflated to tracheal pressures of 10, 15, and 20 mmHg. Tracheal pressures of 10, 15, and 20 mmHg increased system vascular capacitance by 1.4, 3.1, and 4.3 ml/kg and decreased systemic vascular resistance by 0.11, 0.15, and 0.16 mmHg.kg.min-ml-1, respectively, at low carotid sinus pressure (CSP) of 41 mmHg. SENA showed a concomitant decrease. Bilateral vagotomy attenuated the change in SVR by 69%, SVC by 62%, and SENA by 97% when lungs were inflated to a tracheal pressure of 20 mmHg at a low CSP. These results indicate that lung inflation causes a reflex induced increase in SVC as well as a decrease in both SVR and SENA. The lung inflation reflex is mediated primarily through vagal afferent nerve fibers with a small contribution from other afferent nerve pathways.
Author List
Cheng EY, Kay J, Hoka S, Bosnjak ZJ, Coon RL, Seagard JL, Kampine JPMESH terms used to index this publication - Major topics in bold
AnimalsAntihypertensive Agents
Blood Circulation
Blood Pressure
Carotid Sinus
Denervation
Dogs
Efferent Pathways
Hexamethonium
Hexamethonium Compounds
Lung
Reflex
Respiration
Sympathetic Nervous System
Trachea
Vagotomy
Vascular Resistance
Venous Pressure
