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Effects of supervised exercise on lipid profiles and blood pressure control in people with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Diabetes Res Clin Pract 2012 Dec;98(3):349-60

Date

11/03/2012

Pubmed ID

23116535

DOI

10.1016/j.diabres.2012.10.004

Scopus ID

2-s2.0-84870659044 (requires institutional sign-in at Scopus site)   133 Citations

Abstract

AIMS: Our study's purpose was to perform a systematic review to assess the effect of supervised exercise interventions on lipid profiles and blood pressure control.

METHODS: We searched electronic databases and selected studies that evaluated the effect of supervised exercise intervention on cardiovascular risk factors in adult people with type 2 diabetes. We used random effect models to derive weighted mean differences of exercise on lipid profiles and blood pressure control.

RESULTS: Forty-two RCTs (2808 subjects) met inclusion criteria and are included in our meta-analysis. Structured exercise was associated with a change in systolic blood pressure (SBP) of -2.42 mmHg (95% CI, -4.39 to -0.45 mmHg), diastolic blood pressure (DBP) of -2.23 mmHg (95% CI, -3.21 to -1.25 mmHg), high-density lipoprotein cholesterol (HDL-C) of 0.04 mmol/L (95% CI, 0.02-0.07 mmol/L), and low-density lipoprotein cholesterol (LDL-C) of -0.16 mmol/L (95% CI, -0.30 to -0.01 mmol/L). Heterogeneity was partially explained by age, dietary co-intervention and the duration and intensity of the exercise.

CONCLUSIONS: Supervised exercise is effective in improving blood pressure control, lowering LDL-C, and elevating HDL-C levels in people with diabetes. Physicians should recommend exercise for their adult patients with diabetes who can safely do so.

Author List

Hayashino Y, Jackson JL, Fukumori N, Nakamura F, Fukuhara S

Author

Jeffrey L. Jackson MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Blood Pressure
Cholesterol
Diabetes Mellitus, Type 2
Diabetic Angiopathies
Exercise
Humans
Hypercholesterolemia
Hypertension
Lipoproteins
Middle Aged
Randomized Controlled Trials as Topic
Risk Factors