Unilateral megalencephaly associated with neonatal high output cardiac failure. Childs Nerv Syst 1990 May;6(3):123-5
Date
05/01/1990Pubmed ID
2141545DOI
10.1007/BF00308485Scopus ID
2-s2.0-0025372091 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
High-flow cerebral arteriovenous fistulae are well known to present in the neonatal period with macrocephaly, cranial bruits and high-output cardiac failure. This report describes a newborn infant with such a clinical presentation, who had unilateral megalencephaly without macroscopic arteriovenous shunts. Ultrasound Doppler examination of the carotid and cerebral vessels showed diastolic flow, or a decreased pulsatility index, consistent with decreased intracranial vascular resistance. The ipsilateral cerebral arteries and veins were markedly enlarged at angiography and at post-mortem examination, but there was no arteriovenous malformation. The infant expired from high-output cardiac failure and hypoglycemia. It is postulated that the high-output cardiac failure was due to increased blood flow through the enlarged, dysplastic cerebral hemisphere.
Author List
Walters BC, Burrows PE, Musewe N, Chuang SH, Armstrong DMESH terms used to index this publication - Major topics in bold
BrainCardiac Output, Low
Cardiomegaly
Cerebral Angiography
Cerebrovascular Circulation
Humans
Infant, Newborn
Male
Radiography, Thoracic
Tomography, X-Ray Computed
