Regulation of transport in the connecting tubule and cortical collecting duct. Compr Physiol 2012 Apr;2(2):1541-84
Date
12/12/2012Pubmed ID
23227301Pubmed Central ID
PMC3516049DOI
10.1002/cphy.c110052Scopus ID
2-s2.0-84862170060 (requires institutional sign-in at Scopus site) 93 CitationsAbstract
The central goal of this overview article is to summarize recent findings in renal epithelial transport,focusing chiefly on the connecting tubule (CNT) and the cortical collecting duct (CCD).Mammalian CCD and CNT are involved in fine-tuning of electrolyte and fluid balance through reabsorption and secretion. Specific transporters and channels mediate vectorial movements of water and solutes in these segments. Although only a small percent of the glomerular filtrate reaches the CNT and CCD, these segments are critical for water and electrolyte homeostasis since several hormones, for example, aldosterone and arginine vasopressin, exert their main effects in these nephron sites. Importantly, hormones regulate the function of the entire nephron and kidney by affecting channels and transporters in the CNT and CCD. Knowledge about the physiological and pathophysiological regulation of transport in the CNT and CCD and particular roles of specific channels/transporters has increased tremendously over the last two decades.Recent studies shed new light on several key questions concerning the regulation of renal transport.Precise distribution patterns of transport proteins in the CCD and CNT will be reviewed, and their physiological roles and mechanisms mediating ion transport in these segments will also be covered. Special emphasis will be given to pathophysiological conditions appearing as a result of abnormalities in renal transport in the CNT and CCD.
Author List
Staruschenko AMESH terms used to index this publication - Major topics in bold
Acid-Base EquilibriumAnimals
Biological Transport
Calcium
Carrier Proteins
Channelopathies
Homeostasis
Kidney Tubules
Kidney Tubules, Collecting
Membrane Proteins
Nephrons
Potassium
Potassium Channels
Sodium
Sodium Channels
Water-Electrolyte Balance
