Uteroplacental insufficiency alters hepatic fatty acid-metabolizing enzymes in juvenile and adult rats. Am J Physiol Regul Integr Comp Physiol 2001 Jan;280(1):R183-90
Date
12/22/2000Pubmed ID
11124150DOI
10.1152/ajpregu.2001.280.1.R183Scopus ID
2-s2.0-0035005679 (requires institutional sign-in at Scopus site) 98 CitationsAbstract
Multiple adult morbidities are associated with intrauterine growth retardation (IUGR) including dyslipidemia. We hypothesized that uteroplacental insufficiency and subsequent IUGR in the rat would lead to altered hepatic fatty acid metabolism. To test this hypothesis, we quantified hepatic mRNA levels of acetyl-CoA carboxylase (ACC), carnitine palmitoyltransferase (CPTI), the beta-oxidation-trifunctional protein (HADH), fasting serum triglycerides, and hepatic malonyl-CoA levels at different ages in control and IUGR rats. Fetal gene expression of all three enzymes was decreased. Juvenile gene expression of CPTI and HADH continued to be decreased, whereas gene expression of ACC was increased. Serum triglycerides were unchanged. A sex-specific response was noted in the adult rats. In males, serum triglycerides, hepatic malonyl-CoA levels, and ACC mRNA levels were significantly increased, and CPTI and HADH mRNA levels were significantly decreased. In contrast, the female rats demonstrated no significant changes in these variables. These results suggest that uteroplacental insufficiency leads to altered hepatic fatty acid metabolism that may contribute to the adult dyslipidemia associated with low birth weight.
Author List
Lane RH, Kelley DE, Gruetzmacher EM, Devaskar SUMESH terms used to index this publication - Major topics in bold
3-Hydroxyacyl CoA DehydrogenasesAcetyl-CoA Carboxylase
Age Factors
Alcohol Oxidoreductases
Animals
Body Weight
Carnitine O-Palmitoyltransferase
DNA Primers
Fatty Acids
Female
Fetal Growth Retardation
Gene Expression Regulation, Enzymologic
Hyperlipidemias
Liver
Male
Malonyl Coenzyme A
Microvascular Angina
Placental Insufficiency
Pregnancy
RNA, Messenger
Rats
Rats, Sprague-Dawley
Sex Factors
Triglycerides
