The role of oncogenes in chemical carcinogenesis. Environ Health Perspect 1987 Nov;75:81-6
Date
11/01/1987Pubmed ID
3319570Pubmed Central ID
PMC1474454DOI
10.1289/ehp.877581Scopus ID
2-s2.0-0023636973 (requires institutional sign-in at Scopus site) 34 CitationsAbstract
Proto-oncogenes are cellular genes that are expressed during normal growth and developmental processes. Altered versions of normal proto-oncogenes have been implicated in the development of human neoplasia. In this report, we show the detection of activated proto-oncogenes in various spontaneous and chemically induced rodent tumors. The majority of activated proto-oncogenes found in these tumors are members of the ras gene family and have been activated by a point mutation. Characterization of the activating mutation may be useful in determining whether this proto-oncogene was activated by direct interaction of the chemical with the DNA. Comparison of activating lesions in spontaneous versus chemically induced tumors should be helpful in determining whether the chemical acts via a genotoxic or a nongenotoxic mechanism. All of this information may be helpful in the assessment of potential carcinogenic hazards of human exposure to chemicals.
Author List
Stowers SJ, Maronpot RR, Reynolds SH, Anderson MWMESH terms used to index this publication - Major topics in bold
AnimalsCarcinogens
Cell Transformation, Neoplastic
Gene Amplification
Genes, ras
Humans
Neoplasms, Experimental
Oncogenes
Proto-Oncogenes
