High-resolution EEG: cortical potential imaging of interictal spikes. Clin Neurophysiol 2003 Oct;114(10):1963-73
Date
09/23/2003Pubmed ID
14499758DOI
10.1016/s1388-2457(03)00194-9Scopus ID
2-s2.0-0642280641 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
BACKGROUND: It is of clinical importance to localize pathologic brain tissue in epilepsy. Noninvasive localization of cortical areas associated with interictal epileptiform spikes may provide important information to facilitate presurgical planning for intractable epilepsy patients.
METHODS: A cortical potential imaging (CPI) technique was used to deconvolve the smeared scalp potentials into the cortical potentials. A 3-spheres inhomogeneous head model was used to approximately represent the head volume conductor. Five pediatric epilepsy patients were studied. The estimated cortical potential distributions of interictal spikes were compared with the subsequent surgical resections of these same patients.
RESULTS: The areas of negativity in the reconstructed cortical potentials of interictal spikes in 5 patients were consistent with the areas of surgical resections for these patients.
CONCLUSIONS: The CPI technique may become a useful alternative for noninvasive mapping of cortical regions displaying epileptiform activity from scalp electroencephalogram recordings.
Author List
Zhang X, van Drongelen W, Hecox KE, Towle VL, Frim DM, McGee AB, He BMESH terms used to index this publication - Major topics in bold
AdolescentBrain Mapping
Cerebral Cortex
Child
Computer Simulation
Diagnosis, Differential
Electrodes, Implanted
Electroencephalography
Epilepsy
Evoked Potentials
Female
Finite Element Analysis
Humans
Male
Predictive Value of Tests
Reproducibility of Results
Scalp
Sensitivity and Specificity
Skull
Time Factors
