Severe thrombocytopenia in a child secondary to passive platelet antibody transfer from a plasma transfusion. J Pediatr Hematol Oncol 2013 Jul;35(5):e226-8
Date
03/06/2013Pubmed ID
23459377Pubmed Central ID
PMC4508016DOI
10.1097/MPH.0b013e3182830c25Scopus ID
2-s2.0-84880286904 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Although rare, passive transfer of platelet antibodies through blood products can result in thrombocytopenia, acute transfusion reactions, and death. We report a case of severe alloimmune thrombocytopenia from a plasma transfusion. A postliver transplant patient with a normal platelet count received fresh frozen plasma before liver biopsy. Postbiopsy, she developed cardiorespiratory distress, petechiae, and severe thrombocytopenia (platelet count 2000/μL). Her platelet count recovered to normal after 1 week. This diagnosis should be considered whenever an unexpected drop in the platelet count occurs after a plasma-rich transfusion. Conservative transfusion practices and more targeted donor screening may prevent similar events.
Author List
Collins CL, Scott JP, Panepinto JA, Punzalan RCAuthor
Rowena C. Punzalan MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Antigens, Human PlateletBlood Component Transfusion
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Humans
Isoantibodies
Liver Transplantation
Plasma
Thrombocytopenia
