Severe thrombocytopenia in a child secondary to passive platelet antibody transfer from a plasma transfusion. J Pediatr Hematol Oncol 2013 Jul;35(5):e226-8
Date
03/06/2013Pubmed ID
23459377Pubmed Central ID
PMC4508016DOI
10.1097/MPH.0b013e3182830c25Scopus ID
2-s2.0-84880286904 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Although rare, passive transfer of platelet antibodies through blood products can result in thrombocytopenia, acute transfusion reactions, and death. We report a case of severe alloimmune thrombocytopenia from a plasma transfusion. A postliver transplant patient with a normal platelet count received fresh frozen plasma before liver biopsy. Postbiopsy, she developed cardiorespiratory distress, petechiae, and severe thrombocytopenia (platelet count 2000/μL). Her platelet count recovered to normal after 1 week. This diagnosis should be considered whenever an unexpected drop in the platelet count occurs after a plasma-rich transfusion. Conservative transfusion practices and more targeted donor screening may prevent similar events.
Author List
Collins CL, Scott JP, Panepinto JA, Punzalan RCMESH terms used to index this publication - Major topics in bold
Antigens, Human PlateletBlood Component Transfusion
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Humans
Isoantibodies
Liver Transplantation
Plasma
Thrombocytopenia
