Faculty Collaboration Database

Needs and opportunities for research in hypersensitivity pneumonitis. Am J Respir Crit Care Med 2005 Apr 01;171(7):792-8

Date

01/20/2005

Pubmed ID

15657460

DOI

10.1164/rccm.200409-1205WS

Scopus ID

2-s2.0-20144388635 (requires institutional sign-in at Scopus site)   178 Citations

Abstract

Hypersensitivity pneumonitis (HP) develops after inhalation of many different environmental antigens, causing variable clinical symptoms that often make diagnosis uncertain. The prevalence of HP is higher than recognized, especially its chronic form. Mechanisms of disease are still incompletely known. Strategies to improve detection and diagnosis are needed, and treatment options, principally avoidance, are limited. A workshop recommended: a population-based study to more accurately document the incidence and prevalence of HP; better classification of disease stages, including natural history; evaluation of diagnostic tests and biomarkers used to detect disease; better correlation of computerized tomography lung imaging and pathologic changes; more study of inflammatory and immune mechanisms; and improvement of animal models that are more relevant for human disease.

Author List

Fink JN, Ortega HG, Reynolds HY, Cormier YF, Fan LL, Franks TJ, Kreiss K, Kunkel S, Lynch D, Quirce S, Rose C, Schleimer RP, Schuyler MR, Selman M, Trout D, Yoshizawa Y

MESH terms used to index this publication - Major topics in bold

Adult
Alveolitis, Extrinsic Allergic
Animals
Child
Child, Preschool
Disease Models, Animal
Environmental Exposure
Health Services Needs and Demand
Humans
Mice
Occupational Exposure
Prognosis
Research
Risk Assessment
Severity of Illness Index
Tomography, X-Ray Computed