Faculty Collaboration Database

Development of RTOG consensus guidelines for the definition of the clinical target volume for postoperative conformal radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys 2010 Feb 01;76(2):361-8

Date

04/28/2009

Pubmed ID

19394158

Pubmed Central ID

PMC2847420

DOI

10.1016/j.ijrobp.2009.02.006

Scopus ID

2-s2.0-73649096560 (requires institutional sign-in at Scopus site)   338 Citations

Abstract

PURPOSE: To define a prostate fossa clinical target volume (PF-CTV) for Radiation Therapy Oncology Group (RTOG) trials using postoperative radiotherapy for prostate cancer.

METHODS AND MATERIALS: An RTOG-sponsored meeting was held to define an appropriate PF-CTV after radical prostatectomy. Data were presented describing radiographic failure patterns after surgery. Target volumes used in previous trials were reviewed. Using contours independently submitted by 13 radiation oncologists, a statistical imputation method derived a preliminary "consensus" PF-CTV.

RESULTS: Starting from the model-derived CTV, consensus was reached for a CT image-based PF-CTV. The PF-CTV should extend superiorly from the level of the caudal vas deferens remnant to >8-12 mm inferior to vesicourethral anastomosis (VUA). Below the superior border of the pubic symphysis, the anterior border extends to the posterior aspect of the pubis and posteriorly to the rectum, where it may be concave at the level of the VUA. At this level, the lateral border extends to the levator ani. Above the pubic symphysis, the anterior border should encompass the posterior 1-2 cm of the bladder wall; posteriorly, it is bounded by the mesorectal fascia. At this level, the lateral border is the sacrorectogenitopubic fascia. Seminal vesicle remnants, if present, should be included in the CTV if there is pathologic evidence of their involvement.

CONCLUSIONS: Consensus on postoperative PF-CTV for RT after prostatectomy was reached and is available as a CT image atlas on the RTOG website. This will allow uniformity in defining PF-CTV for clinical trials that include postprostatectomy RT.

Author List

Michalski JM, Lawton C, El Naqa I, Ritter M, O'Meara E, Seider MJ, Lee WR, Rosenthal SA, Pisansky T, Catton C, Valicenti RK, Zietman AL, Bosch WR, Sandler H, Buyyounouski MK, Ménard C

MESH terms used to index this publication - Major topics in bold

Aged
Algorithms
Humans
Male
Middle Aged
Postoperative Period
Prostatectomy
Prostatic Neoplasms
Pubic Symphysis
Radiation Oncology
Radiotherapy Dosage
Radiotherapy, Conformal
Rectum
Seminal Vesicles
Societies, Medical
Tomography, X-Ray Computed
Tumor Burden
Urethra
Urinary Bladder
Vas Deferens