A novel locus for adolescent idiopathic scoliosis on chromosome 12p. J Orthop Res 2009 Oct;27(10):1366-72
Date
04/03/2009Pubmed ID
19340878Pubmed Central ID
PMC4120267DOI
10.1002/jor.20885Scopus ID
2-s2.0-70349202169 (requires institutional sign-in at Scopus site) 48 CitationsAbstract
Adolescent idiopathic scoliosis (AIS) is a common disorder with strong evidence for genetic predisposition. Quantitative trait loci (QTLs) for AIS susceptibility have been identified on chromosomes. We performed a genome-wide genetic linkage scan in seven multiplex families using 400 marker loci with a mean spacing of 8.6 cM. We used Genehunter Plus to generate linkage statistics, expressed as homogeneity (HLOD) scores, under dominant and recessive genetic models. We found a significant linkage signal on chromosome 12p, whose support interval extends from near 12 pter, spanning approximately 10 million bases or 31 cM. Fine mapping within the region using 20 additional markers reveals maximum HLOD = 3.7 at 5 cM under a dominant inheritance model, and a split peak maximum HLOD = 3.2 at 8 and 18 cM under a recessive inheritance model. The linkage support interval contains 95 known genes. We found evidence suggestive of linkage on chromosomes 1, 6, 7, 8, and 14. This study is the first to find evidence of an AIS susceptibility locus on chromosome 12. Detection of AIS susceptibility QTLs on multiple chromosomes in this and other studies demonstrate that the condition is genetically heterogeneous.
Author List
Raggio CL, Giampietro PF, Dobrin S, Zhao C, Dorshorst D, Ghebranious N, Weber JL, Blank RDMESH terms used to index this publication - Major topics in bold
AdolescentChild
Chromosome Mapping
Chromosomes, Human, Pair 12
Female
Genetic Linkage
Genetic Predisposition to Disease
Humans
Male
Models, Genetic
Pedigree
Quantitative Trait Loci
Scoliosis
