Increased Young's modulus and hardness of Col1a2oim dentin. J Dent Res 2006 Nov;85(11):1032-6
Date
10/26/2006Pubmed ID
17062745Pubmed Central ID
PMC2246052DOI
10.1177/154405910608501111Scopus ID
2-s2.0-33750694992 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
Mice harboring the Col1a2(oim) mutation (oim) express dentinogenesis imperfecta. To determine the effect of Col1a2 genotype on tissue mechanical properties, we compared Young's modulus and hardness of dentin in the 3 Col1a2 genotypes. Upper incisors were tested by nanoindentation. Genotype had a significant effect on Young's modulus, but there was not a simple mutant allele dosage relationship. The effect of genotype on hardness did not reach significance. Hardness and Young's modulus were greater near the dento-enamel junction than near the pulp chamber. Greater hardness and Young's modulus values near the dento-enamel junction reflected continued mineralization of the dentin following its initial synthesis. Analysis showed the mechanical data to be consistent with Fourier transform infrared and backscattered electron microscopy studies that revealed increased mineralization in oim bone. Analysis of the data suggests that clinical fragility of teeth in oim mice is not due to deficiencies of hardness or Young's modulus, but may be due to defects in post-yield behavior or resistance to fatigue damage.
Author List
Lopez Franco GE, Huang A, Pleshko Camacho N, Stone DS, Blank RDMESH terms used to index this publication - Major topics in bold
AnimalsCollagen Type I
Dental Stress Analysis
Dentin
Dentinogenesis Imperfecta
Elasticity
Female
Hardness
Male
Mice
Mice, Mutant Strains
Mutation
Tooth Cervix
Tooth Crown
