[The role of opiate receptors and ATP-dependent potassium channels of mitochondria in the formation of myocardial adaptive resistance to the arrhythmogenic effect of ischemia and reperfusion]. Izv Akad Nauk Ser Biol 2003(6):720-7
Date
03/05/2004Pubmed ID
14994477Scopus ID
2-s2.0-3042771970 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Preliminary stimulation of opiate receptors (ORs) by intravenous administration of mu agonist DALDA (0.5 mg/kg), delta 1 agonist DPDPE (0.5 mg/kg), and kappa agonist (-)-U-50.488 (1 mg/kg) increases rat myocardial resistance to arrhythmogenic effect of coronary occlusion (10 min) and reperfusion (10 min). Activation of delta 2 ORs (DSLET, 0.5 mg/kg) has no effect on the incidence rate of ischemic and reperfusion arrhythmias. Preliminary administration of glibenclamide (0.3 mg/kg), an inhibitor of KATP channels, blocks the antiarrhythmic effect of DALDA and DPDPE. Repeated short-term exposures of rats to immobilization within two weeks increases the heart tolerance to the arrhythmogenic effect of coronary occlusion and reperfusion. This effect disappears after administration of CTAP (0.5 mg/kg), a mu antagonist, or injection of 5-hydroxydecanoate (5 mg/kg), an inhibitor of mitochondrial KATP channels. The selective antagonists of delta and kappa ORs have no effect on cardiac adaptation-induced resistance to the arrhythmogenic effect of ischemia and reperfusion. We believe that stimulation of mu, delta, and kappa ORs increases myocardial tolerance to the arrhythmogenic effect of ischemia and reperfusion through activation of KATP channels. The antiarrhythmic effect of the adaptation is mediated by stimulation of mu ORs and mitochondrial KATP channels.
Author List
Lishmanov IuB, Naryzhnaia NV, Krylatov AV, Maslov LN, Bogomaz SA, Ugdyzhekova DS, Gross GJ, Stefano JBMESH terms used to index this publication - Major topics in bold
Adaptation, PhysiologicalAdenosine Triphosphate
Animals
Anti-Arrhythmia Agents
Arrhythmias, Cardiac
Coronary Disease
Decanoic Acids
Enkephalin, D-Penicillamine (2,5)-
Enkephalin, Leucine
Glyburide
Hydroxy Acids
Male
Mitochondria
Myocardial Ischemia
Myocardial Reperfusion
Myocardial Reperfusion Injury
Narcotic Antagonists
Oligopeptides
Peptide Fragments
Peptides
Potassium Channels
Rats
Rats, Wistar
Receptors, Opioid
Receptors, Opioid, delta
Receptors, Opioid, mu
Somatostatin
