Comparative recombination rates in the rat, mouse, and human genomes. Genome Res 2004 Apr;14(4):528-38
Date
04/03/2004Pubmed ID
15059993Pubmed Central ID
PMC383296DOI
10.1101/gr.1970304Scopus ID
2-s2.0-1842717957 (requires institutional sign-in at Scopus site) 403 CitationsAbstract
Levels of recombination vary among species, among chromosomes within species, and among regions within chromosomes in mammals. This heterogeneity may affect levels of diversity, efficiency of selection, and genome composition, as well as have practical consequences for the genetic mapping of traits. We compared the genetic maps to the genome sequence assemblies of rat, mouse, and human to estimate local recombination rates across these genomes. Humans have greater overall levels of recombination, as well as greater variance. In rat and mouse, the size of the chromosome and proximity to telomere have less effect on local recombination rate than in human. At the chromosome level, rat and mouse X chromosomes have the lowest recombination rates, whereas human chromosome X does not show the same pattern. In all species, local recombination rate is significantly correlated with several sequence variables, including GC%, CpG density, repetitive elements, and the neutral mutation rate, with some pronounced differences between species. Recombination rate in one species is not strongly correlated with the rate in another, when comparing homologous syntenic blocks of the genome. This comparative approach provides additional insight into the causes and consequences of genomic heterogeneity in recombination.
Author List
Jensen-Seaman MI, Furey TS, Payseur BA, Lu Y, Roskin KM, Chen CF, Thomas MA, Haussler D, Jacob HJMESH terms used to index this publication - Major topics in bold
AnimalsBase Composition
Chromosomes
Crosses, Genetic
Evolution, Molecular
Genetic Variation
Genome
Genome, Human
Humans
Mice
Mice, Inbred Strains
Mice, Obese
Rats
Rats, Inbred BN
Rats, Inbred SHR
Recombination, Genetic
Species Specificity
