A linkage map of mouse chromosome 12: localization of Igh and effects of sex and interference on recombination. Genetics 1988 Dec;120(4):1073-83
Date
12/01/1988Pubmed ID
3147218Pubmed Central ID
PMC1203570DOI
10.1093/genetics/120.4.1073Scopus ID
2-s2.0-0024237745 (requires institutional sign-in at Scopus site) 70 CitationsAbstract
Inheritance of restriction fragment length polymorphisms associated with four anonymous DNA markers (D12Nyu1, 2, 3 and 4), the Fos proto-oncogene, the Mtv-9 viral integration site, and the alpha 1-antitrypsin (Aat-1) and immunoglobulin heavy chain (Igh) gene families in the mouse has been followed in a backcross experiment. A Bayesian multilocus map-building strategy yielded the map: centromere-D12Nyu2-10 cM-D12Nyu1-2 cM-D12Nyu3-15 cM-Fos-1 cM-D12Nyu4-2 cM-Mtv-9-8 cM-Aat-1-17 cM-Igh-C. A map constructed from male meiotic data was substantially shorter than one constructed from female meiotic data. Significant interference was observed for the linkage group. Two groups of markers studied in recombinant inbred strains of mice could be interpolated into the map: Es-25, D12Nyu10, D12Nyu7 and Apob form a cluster proximal to D12Nyu2, and Ly-18, Ah, and D12Nyu5 form a cluster between D12Nyu2 and D12Nyu1. These data establish an unambiguously ordered linkage group including Igh and Aat-1 that spans most of chromosome 12.
Author List
Blank RD, Campbell GR, Calabro A, D'Eustachio PAuthor
Robert D. Blank PhD, MD Emeritus Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AlgorithmsAnimals
Chromosome Mapping
Crosses, Genetic
Data Interpretation, Statistical
Female
Genetic Linkage
Immunoglobulin Heavy Chains
Male
Mice
Mice, Inbred Strains
Proto-Oncogenes
Recombination, Genetic
Sex Factors
alpha 1-Antitrypsin
