Faculty Collaboration Database

Regional perfusion parameters from pulmonary microfocal angiograms. Am J Physiol 1997 Mar;272(3 Pt 2):H1537-48

Date

03/01/1997

Pubmed ID

9087632

DOI

10.1152/ajpheart.1997.272.3.H1537

Scopus ID

2-s2.0-0030911938 (requires institutional sign-in at Scopus site)   16 Citations

Abstract

An indicator-dilution model was developed to describe transport of vascular contrast medium through an organ during acquisition of vascular dynamic contrast images. The model provides the theoretical basis for methods of determining regional blood flow, blood volume, and mean transit time from time-absorbance curves acquired from the images of tissue regions of interest (ROI) distal from the inlet site. The robustness of these methods was evaluated using a computer-simulated vessel network, which simulated the passage of a bolus of contrast medium through arterioles, networks of capillaries, and venules. The network was used to evaluate the reliability of ROI parameter estimation methods when the underlying model assumptions are violated. The shape of the ROI inlet concentration curve and moderate amounts of random noise did not affect the ability of the method to recover accurate parameter estimates. The estimates of ROI flow and transit time were degraded in the presence of significant dispersion of the inlet concentration curve as it traveled through arteries upstream from the microvascular ROI or when the flow was redistributed within the ROI. The estimates of ROI volume were relatively robust. The method was applied to image data of the dog pulmonary vasculature obtained using microfocal X-ray angiography to show that the results obtained from the simulations are consistent with actual data.

Author List

Clough AV, Linehan JH, Dawson CA

Author

Anne Clough PhD Professor in the Mathematics, Statistics, and Computer Science department at Marquette University

MESH terms used to index this publication - Major topics in bold

Angiography
Animals
Dogs
Humans
Microcirculation
Models, Cardiovascular
Models, Theoretical
Pulmonary Artery
Pulmonary Circulation
Radionuclide Imaging
Regional Blood Flow