Illuminating the roles of the Borrelia burgdorferi adhesins. Trends Microbiol 2013 Aug;21(8):372-9
Date
07/24/2013Pubmed ID
23876218Pubmed Central ID
PMC3773214DOI
10.1016/j.tim.2013.06.005Scopus ID
2-s2.0-84881028121 (requires institutional sign-in at Scopus site) 74 CitationsAbstract
The Lyme disease spirochetes, Borrelia burgdorferi (sensu lato), must cause persistent, disseminated infection to be maintained in the natural enzootic cycle. In human Lyme disease, spirochetes spread from the site of a tick bite to colonize multiple tissue sites, causing multisystem clinical manifestations. The Lyme spirochetes produce many adhesive surface proteins that collectively recognize diverse host substrates and cell types and are likely to promote dissemination and chronic infection in a variety of tissues. Recent application of state-of-the-art in vivo imaging technologies is illuminating mechanisms of interaction of B. burgdorferi with the host and the importance of multiple adhesins during mammalian infection.
Author List
Coburn J, Leong J, Chaconas GAuthor
Jenifer Coburn PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adhesins, BacterialAnimals
Bacterial Adhesion
Borrelia burgdorferi Group
Host-Pathogen Interactions
Humans
Microscopy
Optical Imaging
