Faculty Collaboration Database

Effects of d-amphetamine and strychnine on cycloheximide- and diethyldithiocarbamate-induced amnesia in mice. J Comp Physiol Psychol 1977 Dec;91(6):1390-7

Date

12/01/1977

Pubmed ID

202616

DOI

10.1037/h0077418

Scopus ID

2-s2.0-0017612606 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

Groups of C57BL/6J mice were administred cycloheximide (CYC) 30 min before or immediately after training on a passive avoidance task and tested 72 hr later. Some CYC-pretreated groups were given strychnine or d-amphetamine (d-amp) immediately after training and others were given d-amp 1 hr after training. Other groups were given diethyldithiocarbamate (DDC) at various times before or after training. Some DDC-pretreated groups were gived-amp or strychnine as described above for CYC groups. Immediate posttraining administration of 5 mg/kg d-amp, but not strychnine, prevented amnesia in CYC-pretreated mice. The DDC induced an apparent amnesia when administered from 30 min before training to 3 hr after training. Posttraining administration of d-amp or strychnine did not prevent DDC-induced amnesia. These results are discussed in relation to previous suggestions that CYC- and DDC-induced amnesia may be the result of a functional impairment of catecholamine neurotransmitter systems by these drugs.

Author List

Quinton EE, Bloom AS

MESH terms used to index this publication - Major topics in bold

Amnesia
Animals
Cycloheximide
Dextroamphetamine
Ditiocarb
Humans
Male
Mice
Mice, Inbred C57BL
Strychnine
Thiocarbamates