The Mortimer M. Bortin Lecture: to destroy by the reaction of immunity: the search for separation of graft-versus-leukemia and graft-versus-host. Biol Blood Marrow Transplant 2004 Aug;10(8):505-23
Date
07/30/2004Pubmed ID
15282529DOI
10.1016/j.bbmt.2004.05.005Scopus ID
2-s2.0-3543051151 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
The graft-versus-leukemia effect of allogeneic blood or marrow transplantation is a dramatic example of the power of the immune system to eradicate malignant disease. In this personal essay, adapted from the inaugural Mortimer M. Bortin Lecture presented at the 2004 Tandem BMT Meetings, the author recounts early efforts by Bortin and others to manipulate the graft-versus-leukemia effect and separate it from the potentially fatal complications of graft-versus-host disease.
Author List
Truitt RLMESH terms used to index this publication - Major topics in bold
AnimalsBone Marrow Transplantation
Disease Models, Animal
Graft vs Host Disease
Graft vs Host Reaction
Graft vs Leukemia Effect
Graft vs Tumor Effect
Humans
Immunotherapy, Adoptive
Leukemia
Mice
Mice, Inbred AKR
Models, Immunological
Peripheral Blood Stem Cell Transplantation
Radiation Injuries
T-Lymphocytes
T-Lymphocytes, Regulatory
Transplantation Immunology
Transplantation, Homologous
