[Antiarrhythmic and cardioprotective effect of stimulation of delta1-opiate receptors in myocardial ischemia and reperfusion]. Patol Fiziol Eksp Ter 2004(3):12-5
Date
09/28/2004Pubmed ID
15446414Scopus ID
2-s2.0-21644446575 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Pretreatment with intravenous peptide delta1-opioid receptor (OR) agonist DPDPE (0.5 mg/kg) decreases the incidence of occlusion (10 min) and reperfusion (10 min) arrhythmias in rats. The agonist of delta2-OR DSLET has no effect on arrhythmias in coronary artery occlusion and reperfusion. Pretreatment with selective delta-antagonists ICI 174,864 (2.5 mg/kg) eliminates an antiarrhythmic effect of DPDPE. The addition of DPDPE to the perfusion solution in a final concentration of 0.1 mg/l and/or 0.5 mg/l fifteen min before ischemia also decreases the incidence of reperfusion arrhythmias in a concentration-dependent manner. The addition of DPDPE to the perfusion solution in a final concentration of 0.1 mg/l decreases creatine kinase levels in the coronary sinus effluent. However, DPDPE has no cardioprotective effect in a concentration of 0.5 mg/l or after intravenous administration. It is suggested that antiarrhythmic and cardioprotective effects of DPDPE during reperfusion may be due to stimulation of cardiac delta1-receptors.
Author List
Lasukova TV, Krylatov AV, Maslov LN, Lishmanov IuB, Gross GJ, Podoksenov IuK, Podoksenov AIuMESH terms used to index this publication - Major topics in bold
AnimalsAnti-Arrhythmia Agents
Cardiotonic Agents
Creatine Kinase
Dose-Response Relationship, Drug
Enkephalin, D-Penicillamine (2,5)-
Enkephalin, Leucine
Male
Myocardial Ischemia
Myocardial Reperfusion
Myocardial Reperfusion Injury
Rats
Receptors, Opioid, delta
