MAOA T941G polymorphism and the time course of emotional recovery following unpleasant pictures. Psychophysiology 2010 Sep;47(5):857-62
Date
04/09/2010Pubmed ID
20374544DOI
10.1111/j.1469-8986.2010.01005.xScopus ID
2-s2.0-77955164048 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
Difficulty down-regulating negative affect has been linked with anxiety and depression. In addition, recent studies have identified specific polymorphisms of the MAOA gene related to affective psychopathology. Here we examined whether genetic variation in MAOA was associated with the time course of responses to affective stimuli. Emotion-modulation of the startle blink response was measured during and after affective pictures. Women with the G/G genotype of the MAOA T941G single nucleotide polymorphism showed sustained reactivity to unpleasant stimuli, as evidenced by continued blink potentiation during the picture-offset period. These data suggest that the MAOA T941G polymorphism, which has been previously linked with mood disorders, is associated with a maladaptive pattern of affective responding in women.
Author List
Larson CL, Taubitz LE, Robinson JSAuthor
Christine Larson PhD Associate Professor in the Psychology department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AdolescentAlleles
Blinking
Electromyography
Emotions
Female
Gene Frequency
Genotype
Humans
Monoamine Oxidase
Photic Stimulation
Polymorphism, Genetic
Reflex, Startle
Young Adult
