Common variable immunodeficiency. Am J Rhinol Allergy 2013;27(4):260-5
Date
07/26/2013Pubmed ID
23883805Pubmed Central ID
PMC3901442DOI
10.2500/ajra.2013.27.3899Scopus ID
2-s2.0-84883334561 (requires institutional sign-in at Scopus site) 66 CitationsAbstract
Common variable immunodeficiency (CVID) is a common primary immunodeficiency characterized by a failure in B-cell differentiation with defective immunoglobulin production. Affected patients are uniquely susceptible to recurrent infection with encapsulated organisms and have an increased propensity for the development of inflammatory and autoimmune manifestations. The diagnosis of CVID is commonly delayed and the underlying cause of the disorder is not understood. Replacement antibody therapy reduces the risk of serious infections. However, optimal treatment regimens for the uncommon manifestations associated with this disease, such as granulomatous lymphocytic interstitial lung disease, require further research.
Author List
Tam JS, Routes JMAuthor
John Routes MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BiomarkersCommon Variable Immunodeficiency
Diagnosis, Differential
Humans
Immunologic Factors
Mutation
Prognosis
Transmembrane Activator and CAML Interactor Protein
Treatment Outcome
gamma-Globulins
