Generation of effector CD8+ T cells and their conversion to memory T cells. Immunol Rev 2010 Jul;236:151-66
Date
07/20/2010Pubmed ID
20636815Pubmed Central ID
PMC4380273DOI
10.1111/j.1600-065X.2010.00926.xScopus ID
2-s2.0-77953749960 (requires institutional sign-in at Scopus site) 223 CitationsAbstract
Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to elucidate the mechanisms that govern the formation of memory T cells and their ability to acquire longevity, survive the effector-to-memory transition, and mature into multipotent, functional memory T cells that self-renew. Here, we discuss the recent findings in this area and highlight extrinsic and intrinsic factors that regulate the cellular fate of activated CD8+ T cells.
Author List
Cui W, Kaech SMMESH terms used to index this publication - Major topics in bold
AnimalsCD8-Positive T-Lymphocytes
Cell Differentiation
Cell Proliferation
Humans
Immunologic Memory
Interleukin-2
Lymphocyte Activation
Models, Immunological
T-Lymphocytes
