Current perspectives on Gleason grading of prostate cancer. Curr Urol Rep 2011 Jun;12(3):216-22
Date
03/23/2011Pubmed ID
21424766DOI
10.1007/s11934-011-0181-5Scopus ID
2-s2.0-79955811711 (requires institutional sign-in at Scopus site) 27 CitationsAbstract
The 5-tier Gleason grading system for prostate cancer, introduced in 1966, has been proven to be one of the main independent predictors of prostate cancer outcome. This review addresses interobserver concordance in Gleason grading; the persistence of grading discrepancies with frequent upgrading from the biopsy to the prostatectomy specimen; the 2005 International Society of Urologic Pathologists' modifications to Gleason grading; the impact of this modified grading on grade migration and outcome prediction; and molecular correlates of cancer morphology. Data from the most recent years are emphasized.
Author List
Iczkowski KA, Lucia MSMESH terms used to index this publication - Major topics in bold
Biopsy, NeedleFrozen Sections
Humans
Male
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Neoplasm Staging
Observer Variation
Predictive Value of Tests
Prostatectomy
Prostatic Neoplasms
Risk Assessment
Sensitivity and Specificity
Survival Analysis
