Faculty Collaboration Database

Parental tobacco and alcohol use and risk of hepatoblastoma in offspring: a report from the children's oncology group. Cancer Epidemiol Biomarkers Prev 2013 Oct;22(10):1837-43

Date

08/21/2013

Pubmed ID

23950215

Pubmed Central ID

PMC4188411

DOI

10.1158/1055-9965.EPI-13-0432

Scopus ID

2-s2.0-84886445541 (requires institutional sign-in at Scopus site)   14 Citations

Abstract

BACKGROUND: Hepatoblastoma is a rare pediatric liver tumor that has significantly increased in incidence over the last several decades. The International Agency for Research on Cancer (IARC) recently classified hepatoblastoma as a tobacco-related cancer. Parental alcohol use has shown no association. We examined associations between parental tobacco and alcohol use around the time of pregnancy and hepatoblastoma in a large case-control study.

METHODS: Maternal interviews were completed for 383 cases diagnosed in the United States during 2000-2008. Controls (n = 387) were identified through U.S. birth registries and frequency-matched to cases on birth weight, birth year, and region of residence. We used unconditional logistic regression to calculate ORs and 95% confidence intervals (CI) for associations between parental smoking and maternal drinking and offspring hepatoblastoma.

RESULTS: We found no association between hepatoblastoma and maternal smoking at any time (OR, 1.0; 95% CI, 0.7-1.4), within the year before pregnancy (OR, 1.1; 95% CI, 0.8-1.6), early in pregnancy (OR, 1.0; 95% CI, 0.7-1.6), or throughout pregnancy (OR, 0.9; 95% CI, 0.5-1.6). We observed marginally positive associations between hepatoblastoma and paternal smoking in the year before pregnancy (OR, 1.4; 95% CI, 1.0-2.0) and during pregnancy (OR, 1.4; 95% CI, 0.9-2.0). Maternal alcohol use was not associated with hepatoblastoma.

CONCLUSION: Our results do not provide evidence for an etiologic relationship between maternal smoking or drinking and hepatoblastoma, and only weak evidence for an association for paternal smoking in the year before pregnancy.

IMPACT: Our study provides limited support for hepatoblastoma as a tobacco-related cancer; however, it remains wise to counsel prospective parents on the merits of smoking cessation.

Author List

Johnson KJ, Williams KS, Ross JA, Krailo MD, Tomlinson GE, Malogolowkin MH, Feusner JH, Spector LG

MESH terms used to index this publication - Major topics in bold

Adult
Alcohol Drinking
Female
Genetic Predisposition to Disease
Hepatoblastoma
Humans
Liver Neoplasms
Male
Pregnancy
Prenatal Exposure Delayed Effects
Risk Factors
Smoking
United States
Young Adult