Faculty Collaboration Database

Acquired reactive digital fibroma: a clinicopathologic report of 5 cases of a new entity. J Am Acad Dermatol 2013 Oct;69(4):603-8

Date

07/16/2013

Pubmed ID

23849562

DOI

10.1016/j.jaad.2013.05.015

Scopus ID

2-s2.0-84884355355 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

BACKGROUND: Fibroblastic proliferations in the dermis comprise a heterogeneous group of disorders that can pose diagnostic challenges.

OBJECTIVE: We sought to study the clinicopathologic features of this tumor.

METHODS: We reviewed the clinicopathologic features of 5 unusual mesenchymal tumors of the digits that, to our knowledge, correspond to an entity not previously described.

RESULTS: The patients were 5 men. All cases were located in the digits and were associated with history of trauma. Histopathologically, the neoplasms were located mainly in the reticular dermis. The tumors consisted of solitary nodules composed of fascicles of benign-appearing spindle cells devoid of cytologic atypia. The spindle cells formed short fascicles arranged in a haphazard manner. On immunohistochemistry, the tumor cells expressed vimentin and in 2 cases, CD34. The tumor cells were negative for smooth muscle actin (SMA), desmin, h-caldesmon, epithelial membrane antigen (EMA), S100, CD68, CD99, and beta-catenin.

LIMITATIONS: Only 5 cases were studied.

CONCLUSIONS: Awareness of this entity is of importance to avoid misdiagnosis with other conditions. Based on the immunohistochemical pattern, we believe that these tumors are fibroblastic in origin. The peculiar gross appearance and location of the lesions is clinically quite distinctive and may lead to confusion with other neoplastic and reactive processes.

Author List

Plaza JA, Suster S, Prieto VG, Sangueza M

MESH terms used to index this publication - Major topics in bold

Aged
Antigens, CD34
Biopsy, Needle
Fibroma
Humans
Immunohistochemistry
Male
Middle Aged
Nail Diseases
Neoplasm Invasiveness
Neoplasms, Fibrous Tissue
Prognosis
Rare Diseases
Risk Assessment
Sampling Studies
Skin Neoplasms
Thumb
Toes
Vimentin
beta Catenin