The use of ibuprofen plus caffeine to treat tension-type headache. Curr Pain Headache Rep 2001 Oct;5(5):472-8
Date
09/19/2001Pubmed ID
11560814DOI
10.1007/s11916-001-0060-8Scopus ID
2-s2.0-0035491814 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
Simple analgesics such as ibuprofen, aspirin, and acetaminophen have long been used in the treatment of tension-type headache. Studies of combination agents of aspirin with caffeine or acetaminophen with caffeine have also demonstrated efficacy as analgesic agents. Other evidence also suggests that caffeine may have an analgesic effect unto itself in the relief of pain. We undertook the direction of a multicenter, double-blind, placebo-controlled, parallel trial to assess the efficacy and safety of ibuprofen combined with caffeine in the treatment of tension-type headache. The study was designed to also verify the analgesic efficacy of caffeine and further assess the role of tension-type headache as a model for the study of pain.
Author List
Diamond S, Freitag FGMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Analgesics, Non-Narcotic
Caffeine
Central Nervous System Stimulants
Double-Blind Method
Drug Therapy, Combination
Female
Humans
Ibuprofen
Male
Middle Aged
Pain Measurement
Research Design
Tension-Type Headache
Time Factors
