Cementum and dentin in hypophosphatasia. J Dent Res 2005 Nov;84(11):1021-5
Date
10/26/2005Pubmed ID
16246934DOI
10.1177/154405910508401110Scopus ID
2-s2.0-33644644712 (requires institutional sign-in at Scopus site) 120 CitationsAbstract
Hypophosphatasia (HPP) often leads to premature loss of deciduous teeth, due to disturbed cementum formation. We addressed the question to what extent cementum and dentin are similarly affected. To this end, we compared teeth from children with HPP with those from matched controls and analyzed them microscopically and chemically. It was observed that both acellular and cellular cementum formation was affected. For dentin, however, no differences in mineral content were recorded. To explain the dissimilar effects on cementum and dentin in HPP, we assessed pyrophosphate (an inhibitor of mineralization) and the expression/activity of enzymes related to pyrophosphate metabolism in both the periodontal ligament and the pulp of normal teeth. Expression of nucleotide pyrophosphatase phosphodiesterase 1 (NPP1) in pulp proved to be significantly lower than in the periodontal ligament. Also, the activity of NPP1 was less in pulp, as was the concentration of pyrophosphate. Our findings suggest that mineralization of dentin is less likely to be under the influence of the inhibitory action of pyrophosphate than mineralization of cementum.
Author List
van den Bos T, Handoko G, Niehof A, Ryan LM, Coburn SP, Whyte MP, Beertsen WMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Case-Control Studies
Cementogenesis
Child
Child, Preschool
Dental Cementum
Dental Pulp
Dentin
Dentinogenesis
Diphosphates
Humans
Hypophosphatasia
Infant
Microradiography
Minerals
Periodontal Ligament
Phosphoric Diester Hydrolases
Pyrophosphatases
Tooth Calcification
