Neural responses to acute cocaine administration in the human brain detected by fMRI. Neuroimage 2005 Dec;28(4):904-14
Date
08/03/2005Pubmed ID
16061398DOI
10.1016/j.neuroimage.2005.06.039Scopus ID
2-s2.0-28244470111 (requires institutional sign-in at Scopus site) 125 CitationsAbstract
An improved functional MRI (fMRI) method for the reduction of susceptibility artifacts has been utilized to measure blood oxygen level-dependent (BOLD) responses to acute cocaine administration in the human brain of cocaine users. Intravenous administration of cocaine (20 mg/70 kg) activated mesolimbic and mesocortical dopaminergic projection regions and showed temporal positive or negative BOLD responses. These results obtained from human cocaine users supported the involvement of the dopaminergic pathway in cocaine addiction from animal models. In addition, the cocaine administration also induced activations in the hierarchical brain networks in the anterior prefrontal cortex (aPFC) of the Brodmann area 10 (BA10) and orbitofrontal cortex (OFC). It is suggested that the dopaminergic pathways and the hierarchical brain networks may participate in mediating cocaine reward processes, associative learning, motivation, and memory in cocaine addiction in the human brain.
Author List
Kufahl PR, Li Z, Risinger RC, Rainey CJ, Wu G, Bloom AS, Li SJMESH terms used to index this publication - Major topics in bold
AdultAlgorithms
Behavior
Blood Pressure
Brain
Brain Mapping
Cerebral Cortex
Cocaine
Cocaine-Related Disorders
Dopamine
Echo-Planar Imaging
Female
Heart Rate
Humans
Image Processing, Computer-Assisted
Infusions, Intravenous
Limbic System
Male
Oxygen
