Graft-versus-leukemia for AKR spontaneous leukemia-lymphoma. Transplant Proc 1976 Dec;8(4):569-74
Date
12/01/1976Pubmed ID
11589Scopus ID
2-s2.0-0017040149 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Adoptive immunotherapy in the form of a transient graft of mismatched DBA/2 BM + LN cells was used in combination with several chemoradiotherapy regimens to treat AKR mice bearing advanced SLL. Leukemic mice treated in this manner had a significant prolongation of their MST and significantly higher survival rates 60 and 90 days posttreatment than corresponding control groups. Syngeneic- or allogeneic-matched cells did not provide substantial GVL effect. An inverse relationship that influenced survival was observed between the radiation dose and the dose of GVL effector cells used to treat leukemic AKR mice in the treatment model. Recurrence leukemia remains a major problem.
Author List
Truitt RL, Rimm AA, Saltzstein EC, Rose WC, Bortin MMMESH terms used to index this publication - Major topics in bold
Amphotericin BAnimals
Bone Marrow Cells
Bone Marrow Transplantation
Cyclophosphamide
Graft vs Host Reaction
Leukemia, Experimental
Lymph Nodes
Lymphocyte Culture Test, Mixed
Lymphoma
Mice
Mice, Inbred AKR
Mice, Inbred DBA
Nitroso Compounds
Radiation Chimera
Time Factors
Transplantation, Homologous
