Faculty Collaboration Database

Dynamic measurements of hexafluoromisonidazole (CCI-103F) retention in mouse tumours by 1H/19F magnetic resonance spectroscopy. Int J Radiat Biol 1990 Dec;58(6):1025-34

Date

12/01/1990

Pubmed ID

1978851

DOI

10.1080/09553009014552331

Scopus ID

2-s2.0-0025221111 (requires institutional sign-in at Scopus site)   25 Citations

Abstract

Selective retention of hexafluoromisonidazole, CCI-103F, in RIF-1 and SCCVII tumours of C3H/Km mice has been measured by 1H/19F magnetic resonance spectroscopy (MRS) on a Bruker AM-400 multinuclear spectrometer. CCI-103F concentrations in tumours and in normal tissues were measured using an MRS technique in which the water component in the tissues serves as an internal concentration reference. The biodistribution and elimination half-life of the drug in the tissues after i.p. injections were determined. The plasma half-life of the drug (41 min) was measured by high-pressure liquid chromatography. The two tumour lines and liver have longer retention times with half-lives of 47, 129 and 81 min, respectively, while normal tissues, muscle and brain have little retention of CCI-103F and clear the drug very quickly. Dynamic measurements of CCI-103F retention in tumours by MRS may provide a non-invasive probe for assessing tumour hypoxia.

Author List

Jin GY, Li SJ, Moulder JE, Raleigh JA

Author

Shi-Jiang Li PhD, MS Emeritus Professor in the Biophysics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Cell Hypoxia
Fluorocarbons
Injections, Intraperitoneal
Magnetic Resonance Spectroscopy
Mice
Mice, Inbred C3H
Neoplasm Transplantation
Neoplasms, Experimental
Nitroimidazoles