Effects of temperature on vibration-induced damage in nerves and arteries. Muscle Nerve 2006 Mar;33(3):415-23
Date
12/24/2005Pubmed ID
16372319DOI
10.1002/mus.20478Scopus ID
2-s2.0-33644555885 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
Vasospastic episodes in hand-arm vibration syndrome are more prevalent among power-tool workers in cold climates. To test whether cold enhances vibration-induced damage in arteries and nerves, tails of Sprague-Dawley rats were vibrated at room temperature (RT) or with tail cooling (<15 degrees C). Cold vibration resulted in a colder tail than either treatment alone. Vibration at both temperatures reduced arterial lumen size. RT vibration generated more vacuoles in arteries than cold vibration. Vibration and cold induced nitration of tyrosine residues in arteries, suggesting free-radical production. Vibration and cold generated similar percentages of myelinated axons with disrupted myelin. Cold with and without vibration caused intraneural edema and dilation of arterioles and venules with blood stasis, whereas vibration alone did not. The similarities, differences, and interactive effects of cold and vibration on nerve and artery damage indicate that temperature is involved mechanistically in the pathophysiology of hand-arm vibration syndrome.
Author List
Govindaraju SR, Curry BD, Bain JL, Riley DAMESH terms used to index this publication - Major topics in bold
AnimalsArteries
Cold Temperature
Immunohistochemistry
Male
Peripheral Nerve Injuries
Peripheral Nerves
Rats
Rats, Sprague-Dawley
Regional Blood Flow
Tail
Temperature
Tolonium Chloride
Vibration
