Severe aplastic anaemia: a prospective study of the effect of androgens or transplantation on haematological recovery and survival. Clin Haematol 1978 Oct;7(3):587-95
Date
10/01/1978Pubmed ID
363330Scopus ID
2-s2.0-0018021827 (requires institutional sign-in at Scopus site) 43 CitationsAbstract
A prospective study was performed (1) to evaluate the role of androgens in treatment of severe aplastic anaemia, and (2) to compare the efficacy of early bone marrow transplantation with more conventional therapy for severe marrow aplasia. Results fail to support a beneficial effect of androgens on the course of patients with severe aplastic anaemia. In contrast, histocompatible bone marrow transplantation significantly improves survival and haematological recovery. Alternative therapies should be carefully evaluated for non-transplantable patients with severe marrow aplasia.
Author List
Camitta BM, Thomas EDMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Androgens
Anemia, Aplastic
Bone Marrow Transplantation
Child
Child, Preschool
Female
Humans
Male
Middle Aged
Prospective Studies
Transplantation, Homologous
