White matter abnormalities associated with disruptive behavior disorder in adolescents with and without attention-deficit/hyperactivity disorder. Psychiatry Res 2012 Jun 30;202(3):245-51
Date
06/30/2012Pubmed ID
22743120DOI
10.1016/j.pscychresns.2012.01.005Scopus ID
2-s2.0-84865179797 (requires institutional sign-in at Scopus site) 36 CitationsAbstract
Disruptive behavior disorders (DBD) are among the most commonly diagnosed mental disorders in children and adolescents. Some important characteristics of DBD vary based on the presence or absence of comorbid attention-deficit/hyperactivity disorder (ADHD), which may affect the understanding of and treatment decision-making related to the disorders. Thus, identifying neurobiological characteristics of DBD with comorbid ADHD (DBD+ADHD) can provide a basis to establish a better understanding of the condition. This study aimed to assess abnormal white matter microstructural alterations in DBD+ADHD as compared to DBD alone and healthy controls using diffusion tensor imaging (DTI). Thirty-three DBD (19 with comorbid ADHD) and 46 age-matched healthy adolescents were studied using DTI. Fractional anisotropy (FA), and mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) were analyzed using tract-based spatial statistics (TBSS). Significantly lower FA and higher MD, RD and AD in many white matter fibers were found in adolescents with DBD+ADHD compared to controls. Moreover, lower FA and higher RD were also found in the DBD+ADHD versus the DBD alone group. Alterations of white matter integrity found in DBD patients were primarily associated with ADHD, suggesting that ADHD comorbidity in DBD is reflected in greater abnormality of microstructural connections.
Author List
Wang Y, Horst KK, Kronenberger WG, Hummer TA, Mosier KM, Kalnin AJ, Dunn DW, Mathews VPAuthors
Vincent Mathews MD Professor in the Radiology department at Medical College of WisconsinYang Wang MD Professor in the Radiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentAnisotropy
Attention Deficit Disorder with Hyperactivity
Attention Deficit and Disruptive Behavior Disorders
Brain
Brain Mapping
Case-Control Studies
Diffusion Tensor Imaging
Female
Humans
Imaging, Three-Dimensional
Male
Nerve Fibers, Myelinated
Neural Pathways
