Increased precuneus connectivity during propofol sedation. Neurosci Lett 2014 Feb 21;561:18-23
Date
01/01/2014Pubmed ID
24373986Pubmed Central ID
PMC3959727DOI
10.1016/j.neulet.2013.12.047Scopus ID
2-s2.0-84891931691 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
Using functional magnetic resonance imaging in human participants, we show that sedation by propofol to the point of lost overt responsiveness during the performance of an auditory verbal memory task unexpectedly increases functional connectivity of the precuneus with cortical regions, particularly the dorsal prefrontal and visual cortices. After recovery of consciousness, functional connectivity returns to a pattern similar to that observed during the wakeful baseline. In the context of a recent proposal that highlights the uncoupling of consciousness, connectedness, and responsiveness in general anesthesia, the increased precuneus functional connectivity under propofol sedation may reflect disconnected endogenous mentation or dreaming that continues at a reduced level of metabolic activity.
Author List
Liu X, Li SJ, Hudetz AGMESH terms used to index this publication - Major topics in bold
AdultAnesthetics, Intravenous
Brain Mapping
Deep Sedation
Female
Gyrus Cinguli
Humans
Magnetic Resonance Imaging
Male
Memory
Parietal Lobe
Prefrontal Cortex
Propofol
Verbal Behavior
Visual Cortex
Young Adult
