Effect of total flavonoids of hippophae rhamnoides on contractile mechanics and calcium transfer in stretched myocyte. Space Med Med Eng (Beijing) 2000 Feb;13(1):6-9
Date
09/06/2002Pubmed ID
12212626Scopus ID
2-s2.0-0034142963 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
OBJECTIVE: To study the role of total flavonoids of hippophae rhamnoides in improving contractile [correction of contactile] function of stretched cardiac myocyte.
METHOD: Flavonoids were given to stretched myocytes which were proved their contractile function decline and then myocyte contractile mechanics characteristics and calcium transfer were measured.
RESULT: Flavonoids increased myocyte contractility, as indicated by myocyte shortening, velocity of shortening, peak +dL/dt and peak -dL/dt during shortening, in a concentration-dependent manner (r>0.9, P<0.001), and with no relation to the intracellular calcium transfer in the myocytes.
CONCLUSION: Flavonoids of the traditional Chinese drug hippophae rhamnoides is effective in improving the contractile function of stretched cardiac myocyte in low dosage.
Author List
Wang ZR, Wang L, Yin HH, Yang FJ, Gao YQ, Zhang ZJMESH terms used to index this publication - Major topics in bold
AnimalsCalcium
Cells, Cultured
Dose-Response Relationship, Drug
Drugs, Chinese Herbal
Flavonoids
Heart Failure
Hippophae
Medicine, Chinese Traditional
Myocardial Contraction
Myocytes, Cardiac
Quercetin
Rats
Rats, Sprague-Dawley
