Bone marrow transplantation for an infant with neutrophil dysfunction. Exp Hematol 1977 Mar;5(2):109-16
Date
03/01/1977Pubmed ID
321233Scopus ID
2-s2.0-0017346946 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
A child with severe neutrophil dysfunction and intractable infections received bone marrow transplants from histocompatible siblings. After a first transplant preceded by cyclophosphamide (CY), antithymocyte serum (ATS) and procarbazine (PCB) preconditioning, there was no evidence for engraftment and autologous marrow function rapidly returned. Cell mediated lysis showed no evidence of patient sensitization against the marrow donor suggesting that graft rejection did not cause the transplant failure. A second transplant was performed utilizing another matched sibling donor. Total body irradiation was added to CY, ATS, and PCB for preconditioning after in vitro studies of the colony forming capacity (CFUc) of the patient's marrow cells showed normal sensitivity to radiation. Full engraftment ensued with correction of granulocyte function abnormalities. The patient eventually died of intractable pulmonary disease. Our experience with this child suggests that cyclophosphamide alone may be insufficient preparation for marrow transplantation in some patients with non-neoplastic hematologic disorders. Experimental and clinical data supporting this contention are reviewed.
Author List
Camitta BM, Quesenberry PJ, Parkman R, Boxer LA, Stossel TP, Cassady JR, Rappeport JM, Nathan DGMESH terms used to index this publication - Major topics in bold
Antilymphocyte SerumBone Marrow
Bone Marrow Cells
Bone Marrow Transplantation
Cell Division
Clone Cells
Cyclophosphamide
Female
Graft Rejection
Hepatomegaly
Humans
Immunologic Deficiency Syndromes
Infant
Leukocyte Count
Neutrophils
Procarbazine
Splenomegaly
Staphylococcal Infections
Transplantation, Homologous
