Post-transfusion purpura: an enigma of alloimmunization. Am J Hematol 1980;9(3):331-6
Date
01/01/1980Pubmed ID
7015849DOI
10.1002/ajh.2830090312Scopus ID
2-s2.0-0019156403 (requires institutional sign-in at Scopus site) 48 CitationsAbstract
A patient with post-transfusion purpura is reported. This female patient, sensitized by previous blood transfusion, developed symptomatic thrombocytopenia seven days after a second blood transfusion. A platelet antibody, which had anti-P1A1 specificity, was identified by 51Cr-release assay and by indirect immunofluorescence. Hemorrhage stopped abruptly after plasma exchange therapy. Thrombocytopenia did not recur when the patient was further challenged with P1A1-positive blood and plasma. Anti-P1A1 antibody, detectable by immunofluorescence but not by complement-dependent platelet cytoxicity, persisted in high titer for at least one year after recovery. The heterogeneity and pathogenesis of this clinical syndrome are discussed.
Author List
Lau P, Sholtis CM, Aster RHMESH terms used to index this publication - Major topics in bold
AgedAutoantibodies
Blood Group Incompatibility
Blood Platelets
Cytotoxicity Tests, Immunologic
Female
Fluorescent Antibody Technique
Humans
Plasmapheresis
Purpura, Thrombocytopenic
