Predictive value of cross-matching for transfusion of platelet concentrates to alloimmunized recipients. Am J Hematol 1976;1(4):471-9
Date
01/01/1976Pubmed ID
1008059DOI
10.1002/ajh.2830010412Scopus ID
2-s2.0-0017167699 (requires institutional sign-in at Scopus site) 34 CitationsAbstract
Compatibility tests in which donor platelets were tested with recipient sera were performed retroactively after 64 transfusions of platelets from 59 unrelated donors to 10 alloimmunized patients. Techniques used were serotonin release, aggregometry, platelet factor 3 release, and lymphocytotoxicity, each of which has been advocated as a means of testing donor-recipient platelet compatibility. Although "false positive" reactions were few (positive crossmatch but satisfactory transfusion response), "false negative" reactions (negative crossmatch but poor transfusion response) were unacceptably high (43% by lymphocytotoxicity, 60% by serotonin release, 76% by platelet factor 3 release, and 83% by aggregometry). We conclude that current methods of detecting isosensitization to platelet alloantigens are less satisfactory than HLA phenotyping in selecting unrelated platelet donors for an alloimmunized patient population.
Author List
Filip DJ, Duquesnoy RJ, Aster RHMESH terms used to index this publication - Major topics in bold
Blood PlateletsBlood Transfusion
Cytotoxicity Tests, Immunologic
False Negative Reactions
False Positive Reactions
HLA Antigens
Histocompatibility Antigens
Histocompatibility Testing
Humans
Immunization
Platelet Aggregation
Platelet Factor 3
Serotonin
