A study of variables affecting the quality of platelets stored at "room temperature". Transfusion 1975;15(5):414-21
Date
09/01/1975Pubmed ID
823DOI
10.1046/j.1537-2995.1975.15576082215.xScopus ID
2-s2.0-0016630609 (requires institutional sign-in at Scopus site) 339 CitationsAbstract
The effect of variables associated with the donor and with methods of collecting, processing, and storing platelets on the quality of platelets kept at ambient temperature was studied. Changes in structural integrity of platelets, decrease in pH, loss of aggregability, and kinetics in vivo of platelets tagged with 51Cr were used as indicators of the tolerance of platelets to storage. A platelet concentration of less than 2.5 x 10(6) per cu mm, a temperature of storage less than 24 C, and continuous, gentle, agitation were found to be essential for satisfactory preservation of platelet integrity, function, and post-transfusion survival. Platelets from female donors tolerated storage less well than did platelets from male donors, possibly because the lower hematocrit of blood collection from females resulted in greater initial acidity of the concentrate. A number of other variables analyzed appear to be of little or no consequence for successful platelet storage.
Author List
Kunicki TJ, Tuccelli M, Becker GA, Aster RHMESH terms used to index this publication - Major topics in bold
Blood BanksBlood Platelets
Blood Preservation
Cell Survival
Female
Humans
Hydrogen-Ion Concentration
Male
Platelet Aggregation
Sex Factors
Temperature
Time Factors
